放线菌酮和5-氟尿嘧啶对酵母中低分子量核糖核酸形成的影响。
Effects of cycloheximide and 5-fluorouracil on formation of low-molecular-weight ribonucleic acid in yeast.
作者信息
Hendricks D V, Andrean B A, De Kloet S R
出版信息
J Bacteriol. 1969 Feb;97(2):743-8. doi: 10.1128/jb.97.2.743-748.1969.
Abstract
The effects of cycloheximide and 5-fluorouracil on the formation of low-molecular-weight ribonucleic acid (RNA) in yeast were investigated. Both compounds were found to affect the synthesis of low-molecular-weight RNA of ribosomal origin more than transfer RNA but less than the high-molecular-weight ribosomal RNA. 5-Fluorouracil-containing transfer RNA was separated from normal transfer RNA by chromatography on diethylaminoethyl cellulose at 80 C in the presence of 7 m urea.
摘要
研究了环己酰亚胺和5-氟尿嘧啶对酵母中低分子量核糖核酸（RNA）形成的影响。发现这两种化合物对核糖体来源的低分子量RNA合成的影响比对转运RNA的影响更大，但比对高分子量核糖体RNA的影响更小。在7m尿素存在下，于80℃在二乙氨基乙基纤维素上进行色谱分离，可将含5-氟尿嘧啶的转运RNA与正常转运RNA分开。
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