大鼠急性实验性肝静脉闭塞病中的门静脉高压
Portal hypertension in acute experimental veno-occlusive disease of the liver in rats.
作者信息
McLean E K, Hill K R
出版信息
Br J Exp Pathol. 1969 Feb;50(1):37-41.
Abstract
Portal pressure was measured in rats 1-14 days after an LD of dimethylnitrosamine (DMN). A significant rise of portal pressure was found at 5 and 7 days after the dose. Veno-occlusive lesions do not occur before 7 days in these animals. Control observations on rats receiving CCl showed no change in portal pressure attributable to centrilobular necrosis. Possible mechanisms for this rise of pressure are discussed.
摘要
在给予大鼠二甲基亚硝胺（DMN）致死剂量后1至14天测量门静脉压力。给药后第5天和第7天发现门静脉压力显著升高。在这些动物中，静脉闭塞性病变在7天前不会出现。对接受四氯化碳（CCl）的大鼠进行的对照观察显示，由于小叶中心坏死，门静脉压力没有变化。文中讨论了这种压力升高的可能机制。
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