Wheatley D N
Br J Exp Pathol. 1969 Feb;50(1):78-83.
-Ethionine at a dose of 125 mg. i.p. 3 days and, to a lesser extent, 4 days before i.v. treatment with 3 mg. 7,12-dimethylbenz[]anthracene (DMBA) protects the adrenal glands from the adrenocorticolytic action of the polycyclic hydrocarbon in female Sprague-Dawley rats. Treatment of rats less than 3 days or more than 4 days before DMBA challenge has no protective effect. -Methionine at the same dose as ethionine is not protective when given 3 days before DMBA but shows some protective action as a 1-day pretreatment. The protective action of ethionine seems unrelated to the suppression of protein synthesis or to the production of fatty liver. With both methionine, and ethionine, protection of adrenal glands is correlated with the marked vacuolation of the cytoplasm of hepatocytes. Administration of methionine at the same dose as ethionine abolishes the protective action of the latter when they are given 3 days before DMBA. Glycine, like methionine, also protects when given from about the same time as DMBA to 24 hr. beforehand. Its protective action can be prevented by concomitant administration of large doses of arginine. None of the aforementioned protective treatments were effective against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz[]anthracene.
在静脉注射3毫克7,12-二甲基苯并[a]蒽（DMBA）前3天腹腔注射125毫克乙硫氨酸，在较小程度上，注射4天也可保护雌性斯普拉格-道利大鼠的肾上腺免受多环烃的肾上腺皮质溶解作用。在DMBA攻击前不到3天或超过4天对大鼠进行处理则无保护作用。
与乙硫氨酸剂量相同的蛋氨酸在DMBA前3天给药时无保护作用，但作为1天的预处理则显示出一定的保护作用。乙硫氨酸的保护作用似乎与蛋白质合成的抑制或脂肪肝的产生无关。对于蛋氨酸和乙硫氨酸，肾上腺的保护都与肝细胞细胞质明显的空泡化有关。当在DMBA前3天给予与乙硫氨酸相同剂量的蛋氨酸时，会消除后者的保护作用。甘氨酸与蛋氨酸一样，在与DMBA大致相同的时间给药至提前24小时给药时也具有保护作用。同时给予大剂量精氨酸可阻止其保护作用。上述任何一种保护处理均对7-羟甲基-12-甲基苯并[a]蒽诱导的肾上腺坏死无效。
