Melander A, Danielson K, Vessman J, Wählin E
Acta Pharmacol Toxicol (Copenh). 1977 May;40(5):584-8.
The possible influence of food intake on the bioavailability of the anxiolytic drug oxazepam was assessed in eight healthy volunteers taking a single dose of the drug both on an empty stomach and together with a standardized breakfast meal. The serum concentrations of oxazepam were determined by gas chromatography on samples obtained before, and at numerous occasions up to 48 hours after drug administration. The results indicate that concomitant food intake has no essential influence on the bioavailability of oxazepam.
在八名健康志愿者中评估了食物摄入对抗焦虑药物奥沙西泮生物利用度的可能影响。这些志愿者在空腹和与标准化早餐一起服用单剂量该药物的情况下进行了试验。通过气相色谱法测定给药前以及给药后长达48小时内多个时间点采集的样本中奥沙西泮的血清浓度。结果表明，同时摄入食物对奥沙西泮的生物利用度没有实质性影响。
