Melander A, Wåhlin E
Eur J Clin Pharmacol. 1978 Dec 18;14(6):441-4. doi: 10.1007/BF00716387.
The influence of food intake on the bioavailability of dicoumarol from a non-micronized formulation was examined in ten healthy volunteers, by examination of its single-dose kinetics after ingestion of dicoumarol 250 mg with a standardized breakfast and on an empty stomach. Blood samples were collected at regular intervals from 0 to 72 h, and the serum concentration of unmetabolized dicoumarol was determinded by spectrophotometry. Postprandial AUC (area under the curve) values were significantly (p less than 0.01) greater than the preprandial figures, the mean increase being 85 per cent. The results suggest that dicoumarol should always be taken with food.
在10名健康志愿者中，通过检测250毫克双香豆素与标准早餐一起服用后以及空腹服用后的单剂量动力学，研究了食物摄入对非微粉化制剂中双香豆素生物利用度的影响。在0至72小时内定期采集血样，并用分光光度法测定未代谢双香豆素的血清浓度。餐后曲线下面积（AUC）值显著（p小于0.01）高于餐前数值，平均增加85%。结果表明，双香豆素应始终与食物一起服用。
