放线菌素中D-异亮氨酸和N-甲基-L-别异亮氨酸残基的生源起源。
Biogenetic origin of the D-isoleucine and N-methyl-L-alloisoleucine residues in the actinomycins.
作者信息
Yajima T, Mason K, Katz E
出版信息
Antimicrob Agents Chemother. 1976 Feb;9(2):224-32. doi: 10.1128/AAC.9.2.224.
Abstract
Studies with (14)C-labeled isoleucine stereisomers have established that l-alloisoleucine, d-alloisoleucine, and d-isoleucine may function as precursors for the biogenesis of d-isoleucine and N-methyl-l-alloisoleucine residues in actinomycin. l-[(14)C]isoleucine appears to be employed chiefly for d-alloisoleucine (and N-methylisoleucine [?] formation); however, its role in the biosynthesis of d-isoleucine and N-methylalloisoleucine remains unclear. The potential pathway of biosynthesis of d-isoleucine and N-methyl-l-isoleucine is discussed.
摘要
用（14）C标记的异亮氨酸立体异构体进行的研究表明，L-别异亮氨酸、D-别异亮氨酸和D-异亮氨酸可能作为放线菌素中D-异亮氨酸和N-甲基-L-别异亮氨酸残基生物合成的前体。L-[（14）C]异亮氨酸似乎主要用于D-别异亮氨酸（和N-甲基异亮氨酸[？]形成）；然而，其在D-异亮氨酸和N-甲基别异亮氨酸生物合成中的作用仍不清楚。本文讨论了D-异亮氨酸和N-甲基-L-异亮氨酸的潜在生物合成途径。
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