孕酮疗法对己烯雌酚诱导的离体大鼠子宫制剂敏感性的影响。
Effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated rat uterus preparations.
作者信息
Khan I, Ahmed N
出版信息
Br J Pharmacol. 1969 Feb;35(2):332-8. doi: 10.1111/j.1476-5381.1969.tb07992.x.
Abstract
- Progesterone treatment (50 mg/kg) in ovariectomized rats antagonizes the effects of stilboestrol 100 mug/kg on the vaginal mucosa and uterine weight; but the sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine is increased by factors 4, 11 and 3, respectively.2. In intact animals a similar progesterone treatment (50 mg/kg) antagonizes the effects of stilboestrol 100 mug/kg on vaginal smears, uterine weight and uterine sensitivity. The uterine sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine is, however, decreased by a factor of 2, 1.4 and 17.7, respectively.3. These experiments show that the ovary is essential for the desensitizing effects of progesterone. The suggestion is put forward that another substance is released from the ovary by progesterone.
摘要
对去卵巢大鼠进行孕酮处理（50毫克/千克）可拮抗己烯雌酚100微克/千克对阴道黏膜和子宫重量的影响；但对乙酰胆碱、催产素和5-羟色胺的敏感性分别提高了4倍、11倍和3倍。
在未切除卵巢的动物中，类似的孕酮处理（50毫克/千克）可拮抗己烯雌酚100微克/千克对阴道涂片、子宫重量和子宫敏感性的影响。然而，子宫对乙酰胆碱、催产素和5-羟色胺的敏感性分别降低了2倍、1.4倍和17.7倍。
这些实验表明，卵巢对于孕酮的脱敏作用至关重要。有人提出，孕酮会促使卵巢释放另一种物质。
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Effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated rat uterus preparations.孕酮疗法对己烯雌酚诱导的离体大鼠子宫制剂敏感性的影响。
Br J Pharmacol. 1969 Feb;35(2):332-8. doi: 10.1111/j.1476-5381.1969.tb07992.x.
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引用本文的文献
1
Study of the effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated uteri of hypophysectomized rats.孕酮疗法对己烯雌酚诱导的垂体切除大鼠离体子宫敏感性影响的研究。
Br J Pharmacol. 1970 Feb;38(2):316-20. doi: 10.1111/j.1476-5381.1970.tb08519.x.
本文引用的文献
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