孕酮疗法对己烯雌酚诱导的垂体切除大鼠离体子宫敏感性影响的研究。
Study of the effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated uteri of hypophysectomized rats.
作者信息
Khan I, Qureshi Z, Haq M
出版信息
Br J Pharmacol. 1970 Feb;38(2):316-20. doi: 10.1111/j.1476-5381.1970.tb08519.x.
Abstract
- In intact rats progesterone (50 mg/kg) antagonized the effect of stilboestrol (100 mug/kg) on the vaginal smears and the uterine sensitivity. The uterine sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine was decreased by 6.8, 64 and 14.8 times, respectively, as compared with uteri removed after stilboestrol injections.2. Progesterone therapy in hypophysectomized rats also antagonized the effect of stilboestrol on the vaginal mucosa and on the uterine sensitivity to drugs. The sensitivity to acetylcholine, oxytocin and 5-hydroxytryptamine was decreased by 6.2, 50 and 14.5 times, respectively. Similar results were obtained on uteri removed from sham-hypophysectomized rats.3. On the basis of these results it is suggested that the hypophysis does not play any part in the desensitization of the myometrium to the oxytocic drugs and in the changes found in the vaginal mucosa after progesterone therapy.
摘要
在完整大鼠中，孕酮（50毫克/千克）拮抗己烯雌酚（100微克/千克）对阴道涂片和子宫敏感性的作用。与己烯雌酚注射后摘除的子宫相比，子宫对乙酰胆碱、催产素和5-羟色胺的敏感性分别降低了6.8倍、64倍和14.8倍。
垂体切除大鼠的孕酮治疗也拮抗了己烯雌酚对阴道黏膜和子宫对药物敏感性的作用。对乙酰胆碱、催产素和5-羟色胺的敏感性分别降低了6.2倍、50倍和14.5倍。从假垂体切除大鼠摘除的子宫也得到了类似结果。
根据这些结果，提示垂体在子宫肌层对催产药物脱敏以及孕酮治疗后阴道黏膜出现的变化中不起任何作用。
相似文献
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Study of the effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated uteri of hypophysectomized rats.孕酮疗法对己烯雌酚诱导的垂体切除大鼠离体子宫敏感性影响的研究。
Br J Pharmacol. 1970 Feb;38(2):316-20. doi: 10.1111/j.1476-5381.1970.tb08519.x.
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本文引用的文献
1
Actions of some analogues of tryptamine on the isolated rat uterus and on the isolated rat fundus strip preparations.色胺的某些类似物对离体大鼠子宫和离体大鼠子宫底条制备物的作用。
Br J Pharmacol Chemother. 1959 Mar;14(1):99-107. doi: 10.1111/j.1476-5381.1959.tb00934.x.
2
Investigation into the effects of reserpine on isolated uterine preparation of hypophysectomized female rats.利血平对去垂体雌性大鼠离体子宫标本作用的研究。
Life Sci. 1967 Dec 1;6(23):2469-82.
3
Ovarian secretion of progesterone and 20-alpha-hydroxypregn-4-en-3-one during pseudopregnancy and pregnancy in rats.大鼠假孕和妊娠期间卵巢孕酮及20-α-羟基孕-4-烯-3-酮的分泌
Endocrinology. 1967 Sep;81(3):617-22. doi: 10.1210/endo-81-3-617.
4
Effects of progesterone therapy on the stilboestrol-induced sensitivity of isolated rat uterus preparations.孕酮疗法对己烯雌酚诱导的离体大鼠子宫制剂敏感性的影响。
Br J Pharmacol. 1969 Feb;35(2):332-8. doi: 10.1111/j.1476-5381.1969.tb07992.x.
5
Study of the effects of progesterone therapy on the oestrogen-induced sensitivity of rat uterus.孕酮疗法对雌激素诱导的大鼠子宫敏感性影响的研究。
Br J Pharmacol. 1968 Sep;34(1):206P-207P.
6
Effects of reserpine on the sensitivity of rat isolated uteri preparations to oxytocic drugs.利血平对大鼠离体子宫制剂对催产药物敏感性的影响。
J Pharm Pharmacol. 1967 Dec;19(12):815-20. doi: 10.1111/j.2042-7158.1967.tb09549.x.
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