Grote W, Schulz L C, Drommer W, Uberschär S, Schäfer E A
Arzneimittelforschung. 1977;27(3):613-7.
Göttingen miniature pigs were used to test a combination of the active principles coumarin and troxerutin (Venalot) for teratogenic and embryotoxiic side-effects. The experimental group consisted of 17 mother pigs with 95 fetuses, the control group of 6 untreated sows with 45 fetuses. The combination of coumarin and troxerutin was administered orally at a level of the 100-fold therapeutic dose (i.e. 25 mg coumarin + 150 mg troxertutin/kg/day) from day 6 to day 30 of gestation. The pathological and histological examinations of the uteri and fetuses revealed no indications of any embryotoxic or teratogenic damage caused by the tested combinations. Morphological and clinico-chemical investigations did also not result in any findings definitely attributable to the medication.
使用哥廷根小型猪来测试香豆素和曲克芦丁（维脑路通）活性成分组合的致畸和胚胎毒性副作用。实验组由17头母猪和95头胎儿组成，对照组由6头未治疗的母猪和45头胎儿组成。在妊娠第6天至第30天，以100倍治疗剂量（即25毫克香豆素 + 150毫克曲克芦丁/千克/天）口服给予香豆素和曲克芦丁的组合。对子宫和胎儿的病理及组织学检查未发现受试组合造成任何胚胎毒性或致畸性损伤的迹象。形态学和临床化学研究也未得出任何明确归因于该药物的结果。
