Pethö A
Arzneimittelforschung. 1981;31(8):1303-7.
A clinical double-blind study of the effectiveness of the benzopyrone product 5.6-benzo-alpha-pyron + 3',4',7-tris-(hydroxy-ethyl)-rutin (coumarin + troxerutin, Venalot) was investigated in 560 patients following medio-lateral episiotomy. The compound was investigated at various dose levels, and its active components coumarin and troxerutin separately. It was shown that the symptoms of posttraumatic inflammation like edema, rubor around the incision wound, and posttraumatic pain as well as consumption of analgesics and the postoperative scar formation were beneficially influenced by the drug. As a guideline for dosing, 1 mg/kg/d related to the coumarin content, was calculated. The efficacy of the combination of the active compounds was superior to that found with the components applied separately. The significance of episiotomy as clinical model for posttraumatic inflammation in general is discussed and application of the benzopyrone product above all in plastic surgery is suggested.
对560例行会阴侧切术的患者进行了一项关于苯并吡喃酮产品5,6-苯并-α-吡喃 + 3',4',7-三（羟乙基）芦丁（香豆素 + 曲克芦丁，维脑路通）有效性的临床双盲研究。对该化合物在不同剂量水平进行了研究，并分别研究了其活性成分香豆素和曲克芦丁。结果表明，该药物对创伤后炎症的症状，如水肿、切口周围红肿、创伤后疼痛以及镇痛药的使用和术后瘢痕形成均有有益影响。计算得出以香豆素含量计的给药指导剂量为1 mg/kg/d。活性化合物组合的疗效优于单独使用各成分时的疗效。讨论了会阴侧切术作为一般创伤后炎症临床模型的意义，并建议上述苯并吡喃酮产品尤其在整形外科中的应用。
