氢氧化铝吸附白喉、破伤风和百日咳联合疫苗用于婴儿免疫接种的优势。
Advantages of aluminium hydroxide adsorbed combined diphtheria, tetanus, and pertussis vaccines for the immunization of infants.
作者信息
Butler N R, Voyce M A, Burland W L, Hilton M L
出版信息
Br Med J. 1969 Mar 15;1(5645):663-6. doi: 10.1136/bmj.1.5645.663.
Abstract
Three combined triple antigen vaccines were used to inoculate infants receiving primary immunization at 3 to 6 months of age. Laboratory potency and toxicity tests and clinical evaluation again showed that the mouse weight gain test is able to predict which vaccines will give reactions in children. The addition of aluminium hydroxide to the vaccine both increased potency and reduced the tendency to cause reactions. Assays on sera showed that almost all children produced agglutinins to Bordetella pertussis types 1, 2, and 3 when the vaccine contained aluminium hydroxide.
摘要
使用三种联合三联疫苗对3至6个月大接受初次免疫的婴儿进行接种。实验室效价和毒性测试以及临床评估再次表明，小鼠体重增加试验能够预测哪些疫苗会在儿童中引起反应。在疫苗中添加氢氧化铝既提高了效价又降低了引起反应的倾向。血清检测表明，当疫苗含有氢氧化铝时，几乎所有儿童都产生了针对百日咳博德特氏菌1型、2型和3型的凝集素。
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