对百日咳博德特氏菌抗血清“杀菌活性模式”负责的抗体的特性分析。
Characterization of the antibodies responsible for the 'bactericidal activity patterns' of antisera to Bordetella pertussis.
作者信息
Dolby J M, Vincent W A
出版信息
Immunology. 1965 May;8(5):499-510.
Antisera to fractions of have been investigated to determine the nature of the antibodies responsible for bactericidal activity and the cause of prozoning observed with some (type 2) sera. Bactericidal activity in both type 1 and type 2 sera tends to be correlated with the titre of agglutinins, anti-haemagglutinin and intracerebral protective antibody; it is not constantly associated with any other function. It is almost certainly not a property of antitoxin, antibody to histamine sensitizing factor or intranasal protective antibody. The inhibition zone of type 2 antisera appears to be due to an antibody present in the crude β-globulin fraction of antiserum. The antigen stimulating this antibody is probably a protein but is not the normal agglutinin, haemagglutinin or the histamine sensitizing factor.
已对[具体物质]各组分的抗血清进行了研究，以确定具有杀菌活性的抗体的性质，以及某些（2型）血清中出现前带现象的原因。1型和2型血清中的杀菌活性往往与凝集素、抗血凝素和脑内保护性抗体的滴度相关；它并非始终与任何其他功能相关联。几乎可以肯定，它不是抗毒素、组胺致敏因子抗体或鼻内保护性抗体的特性。2型抗血清的抑制区似乎是由于抗血清粗β球蛋白组分中存在的一种抗体所致。刺激这种抗体产生的抗原可能是一种蛋白质，但不是正常的凝集素、血凝素或组胺致敏因子。
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