Meingassner J G, Mieth H
Arzneimittelforschung. 1977;27(3):638-9.
Experimental chemotherapeutical studies were carried out with metronidazole, tinidazole, nitrimidazine and ornidazole in rats infected with Trichomonas vaginalis intravaginally. All compounds tested showed a systemic trichomonacidal activity within rather a narrow dosage range after three oral doses and also after a single dose, i.e., 1.4-3.0 mg/kg and 7.7-15.9 mg/kg body weight (DC50), respectively.
采用甲硝唑、替硝唑、硝咪唑嗪和奥硝唑对经阴道感染阴道毛滴虫的大鼠进行了实验性化疗研究。在口服三次及单次给药后，所有受试化合物在相当窄的剂量范围内均显示出全身杀滴虫活性，即分别为1.4 - 3.0毫克/千克和7.7 - 15.9毫克/千克体重（半数致死量）。
