Meingassner J G
Experientia. 1977 Sep 15;33(9):1160-1. doi: 10.1007/BF01922302.
The trichomonacidal efficacy of metronidazole, tinidazole, nimorazole and ornidazole was studied in mice infected s.c., or for comparison purposes intravaginally. In both test systems, the drugs revealed nearly the same order of efficacy, whereby the compounds showed a marked decrease of activity when analyzed in s.c. infected mice.
研究了甲硝唑、替硝唑、硝咪唑和奥硝唑对皮下感染或为作比较而经阴道感染的小鼠的杀滴虫效力。在这两种试验系统中,这些药物显示出几乎相同的效力顺序,不过在分析皮下感染的小鼠时,这些化合物的活性显著降低。