5,6-单环氧-3-脱氢视黄醛的制备、性质及代谢
Preparation, properties and metabolism of 5,6-monoepoxy-3-dehydroretinal.
作者信息
Mallia A K, Lakshmanan M R, John K V, Cama H R
出版信息
Biochem J. 1969 Jan;111(1):23-6. doi: 10.1042/bj1110023.
Abstract
- 5,6-Monoepoxy-3-dehydroretinal was synthesized from 3-dehydroretinyl acetate and characterized. 2. When fed to vitamin A-deficient rats, 5,6-monoepoxy-3-dehydroretinal was converted into 5,6-monoepoxy-3-dehydrovitamin A and stored in the liver. 3. It was demonstrated that the rat possesses the necessary enzymes for the reduction and oxidation of 5,6-monoepoxy-3-dehydroretinal to the corresponding alcohol and acid respectively. 4. The biological potency of the epoxy-3-dehydroretinal by the rat-growth assay (determined by USP XIV procedure) was 1.07% of that of vitamin A.
摘要
- 由乙酸3-脱氢视黄酯合成了5,6-单环氧-3-脱氢视黄醛并进行了表征。2. 将5,6-单环氧-3-脱氢视黄醛喂给维生素A缺乏的大鼠后，它被转化为5,6-单环氧-3-脱氢维生素A并储存在肝脏中。3. 已证明大鼠具有将5,6-单环氧-3-脱氢视黄醛分别还原和氧化为相应醇和酸所需的酶。4. 通过大鼠生长试验（按照美国药典第十四版程序测定），环氧-3-脱氢视黄醛的生物效价为维生素A的1.07%。
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