Saltykov B B, Malkina L A
Arkh Patol. 1975;37(11):38-44.
A histochemical and immunoluminescent investigation of hyalin of arterioles ans small arteries of the kidney, spleen, pancreas and skin were carried out. In 20 patients with diabetes mellitus of a various degree of gravity and duration hyalinosis represented a manifestation of microangiopathy; it was particularly pronounced in the vessels of the spleen and kidney, and in a lesser degree--in the vessels of the pancreas and skin. The intensity of hyalinosis was directly proportional to the duration of the disease; Immunomorphologically, hyaline masses devealed globulins, gamma M-, gamma G-immunoglobulins, complement, albumins, beta-lipoproteins, fibrinogens, which indicates to a hematogenic nature of the vascular hyalin. The presence in hyalin of G an M-immunoglobulins and complement may testify to the participation in its formation of immune mechanisms, together with metabolic ones.
对肾脏、脾脏、胰腺和皮肤的小动脉及小动脉透明质进行了组织化学和免疫荧光研究。在20例不同严重程度和病程的糖尿病患者中，透明样变性是微血管病变的一种表现；在脾脏和肾脏的血管中尤为明显，而在胰腺和皮肤的血管中程度较轻。透明样变性的强度与疾病持续时间成正比；免疫形态学上，透明质块显示出球蛋白、γM-、γG-免疫球蛋白、补体、白蛋白、β-脂蛋白、纤维蛋白原，这表明血管透明质具有血源性。透明质中存在G和M免疫球蛋白及补体可能证明免疫机制与代谢机制共同参与了其形成。
