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用电耳蜗描记法检测豚鼠噪声诱导的生理应激和听力损失(作者译)

[Detection of noise-induced physiological stress and hearing loss in guinea pigs by means of an electro-cochleographic method (author's transl)].

作者信息

Kraak W, Hofmann G

出版信息

Arch Otorhinolaryngol. 1977 May 31;215(3-4):301-10.

PMID:577697
Abstract

One of the most essential prerequisites to the suitability of test animals used for studying the damage effect of noise on audition is the threshold determination with reasonable expenditure. Mention is made of an electro-cochleographic method to determine the click threshold and click threshold shift [TTS(C) and PTS(C)], resp., after an uninjured guinea pig has been subjected to noise. The temporary threshold shift following a short-term sonic exposure and the permanent threshold shift following a permanent sonic exposure reveal a far heavier effect on the guinea pig ear than on the human ear. However, the trends in stress and affection are so much alike in guinea pig and man that the former's involvement in studying the effects of audition-affecting noise on the human ear seems to be primising.

摘要

用于研究噪声对听觉损伤作用的实验动物适用性的最重要前提之一,是以合理的成本进行阈值测定。文中提到一种电耳蜗描记法,用于在未受伤的豚鼠暴露于噪声后分别测定其短声阈值以及短声阈移[TTS(C)和PTS(C)]。短期声暴露后的暂时性阈移和长期声暴露后的永久性阈移对豚鼠耳朵的影响远比人类耳朵严重。然而,豚鼠和人类在应激和受影响趋势方面非常相似,以至于让豚鼠参与研究影响听觉的噪声对人耳的作用似乎很有前景。

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