麦角酸二乙酰胺：对发育中小鼠晶状体的影响。

Lysergic acid diethylamide: effects on the developing mouse lens.

作者信息

Hanaway J K

出版信息

Science. 1969 May 2;164(3879):574-5. doi: 10.1126/science.164.3879.574.

DOI:10.1126/science.164.3879.574

Abstract

High doses (5 x 10-(6) gram) of LSD-25 given to Swiss-Webster females on gestation days 6, 7, 8, or 9 caused a high incidence of anterior subcapsular lens abnormalities. Accompanying this, the lens epithelium was often hyperplastic, and the lens bow was widened posteriorly in a fashion similar to cataracts induced by x-radiation. Confirmation of this effect of LSD-25 was obtained by a (duplicate) experiment 1 year after the observations reported.

摘要

在妊娠第6、7、8或9天给瑞士韦伯斯特雌性小鼠注射高剂量（5×10⁻⁶克）的麦角酸二乙酰胺（LSD-25），导致前囊下晶状体异常的发生率很高。与此同时，晶状体上皮常常增生，晶状体弓向后变宽，其方式类似于X射线诱发的白内障。在报告观察结果1年后通过一项（重复）实验证实了LSD-25的这种作用。