Alexander G J, Miles B E, Gold G M, Alexander R B
Science. 1967 Jul 28;157(3787):459-60. doi: 10.1126/science.157.3787.459.
One of five rats given a single subcutaneous injection of lysergic acid diethylamide (LSD) early in pregnancy appeared to abort early; two delivered stunted stillborn offspring at term, one delivered a littler of seven healthy and one underdeveloped young, and the last one delivered an apparently normal litter. All five matched controls, given saline injections, went to term and delivered healthy litters of 11 to 16 offspring; there were no abortions and no stillbirths. In a replicate experiment, one of five rats given LSD on the 4th day of gestation aborted, two delivered some stillborn offspring, one gave an abnormally small litter of four, and the last one produced an apparently normal litter of ten. All matched controls delivered healthy litters, totaling 66. Some surviving offspring treated with LSD failed to develop as well as control animals. Treatment of five additional rats with LSD late in pregnancy had no obvious effect on the offspring.
五只在孕期早期接受单次皮下注射麦角酸二乙酰胺（LSD）的大鼠中，有一只似乎早早流产；两只足月产下发育不良的死胎，一只产下一窝七只健康幼崽和一只发育不全的幼崽，最后一只产下一窝显然正常的幼崽。所有五只接受生理盐水注射的匹配对照大鼠都足月分娩，产下11至16只健康幼崽的窝仔；没有流产和死产情况。在重复实验中，五只在妊娠第4天接受LSD注射的大鼠中有一只流产，两只产下一些死胎，一只产下一窝异常少的四只幼崽，最后一只产下一窝显然正常的十只幼崽。所有匹配对照都产下健康窝仔，总数为66只。一些经LSD处理存活下来的后代发育不如对照动物。另外五只大鼠在孕期晚期接受LSD处理对后代没有明显影响。
