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[关于成熟度与缺血耐受性关系的研究]

[Studies on the relationship of maturity to the tolerance of ischemia].

作者信息

Fischer J H

出版信息

Fortschr Med. 1977 Aug 4;95(29):1833-6. doi: 10.103/00006450-11000-0000.

DOI:10.103/00006450-11000-0000
PMID:577915
Abstract

In newborn rabbits during asphyxia caused by ligature of the trachea circulation was maintained 2-3 times as long as in adult rabbits because in contrast to the adults myocardial energy loss in asphyxia is rather low caused by a small energy consumption for circulatory work. In the cerebral cortex of newborn rabbits glycolysis is able to meet a good part of energy demand, with the energetic situation predominantly depending on glucose supply by maintenance of circulation. Thus in addition sufficient blood glucose levels deliberated from glycogen stores in liver and lung are an important factor for the central nervous revivability. Kidney and skeletal muscle tolerate anaerobic periods for rather long time because of their high glycogen stores and low metabolic activity but do not contribute to glucose supply of other tissues.

摘要

在新生兔中,通过结扎气管造成窒息时,循环维持的时间是成年兔的2至3倍,这是因为与成年兔不同,窒息时新生兔心肌能量损失相当低,这是由于循环工作的能量消耗较小。在新生兔的大脑皮层中,糖酵解能够满足大部分能量需求,能量状况主要取决于循环维持所提供的葡萄糖供应。因此,肝脏和肺中糖原储备释放出的足够血糖水平也是中枢神经恢复能力的一个重要因素。肾脏和骨骼肌由于糖原储备高且代谢活动低,能够耐受较长时间的无氧期,但它们并不为其他组织提供葡萄糖。

相似文献

1
[Studies on the relationship of maturity to the tolerance of ischemia].[关于成熟度与缺血耐受性关系的研究]
Fortschr Med. 1977 Aug 4;95(29):1833-6. doi: 10.103/00006450-11000-0000.
2
Metabolic patterns in several tissues of newborn rabbits during ischemia.新生兔缺血期间多个组织中的代谢模式。
Biol Neonate. 1975;27(3-4):235-50. doi: 10.1159/000240780.
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Metabolic patterns of several tissues of rabbits and guinea pigs during postnatal development.兔和豚鼠出生后发育过程中几种组织的代谢模式。
Biol Neonate. 1973;22(3):201-21. doi: 10.1159/000240554.
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[Pathological and biochemical studies of acute anoxia in newborns].新生儿急性缺氧的病理与生化研究
Nihon Sanka Fujinka Gakkai Zasshi. 1969 Jun;21(6):653-60.
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[Influence of cortisone on the levels of pyruvic and lactic acids and the activity of the enzymes of gluconeogenesis in the tissues of newborn and adult animals].[可的松对新生动物和成年动物组织中丙酮酸和乳酸水平以及糖异生酶活性的影响]
Ukr Biokhim Zh. 1975 Jan-Feb;47(1):116-21.
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HYPOTHERMIA IN THE TREATMENT OF ASPHYXIA NEONATORUM.低温疗法治疗新生儿窒息
Biol Neonat. 1964;6:148-63. doi: 10.1159/000239893.
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Effects of asphyxia at birth on postnatal glucose regulation in the rat.出生时窒息对大鼠出生后葡萄糖调节的影响。
J Dev Physiol. 1984 Dec;6(6):473-83.
8
Patterns of variation in glycogen, free glucose and lactate in organs of supercooled hatchling painted turtles (Chrysemys picta).过冷却孵化期锦龟(彩龟)器官中糖原、游离葡萄糖和乳酸的变化模式
J Exp Biol. 2005 Aug;208(Pt 16):3169-76. doi: 10.1242/jeb.01743.
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Changes in tissue glycogen of recovering asphyxiated newborn monkeys.
Biol Neonate. 1975;27(3-4):279-88. doi: 10.1159/000240784.
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[Physiopathology of cerebral hypoxia in the newborn infant].[新生儿脑缺氧的病理生理学]
Arch Fr Pediatr. 1986 May;43(5):353-9.

引用本文的文献

1
[Deuterium-oxide protection in asphyxia (author's transl)].
Experientia. 1981 Mar 15;37(3):263-5. doi: 10.1007/BF01991645.