Carstensen M, Leichweiss H P, Molsen G, Schröder H
Arch Gynakol. 1977 May 29;222(3):187-96. doi: 10.1007/BF00717597.
Isolated cotylidons of human term placentas are perfused artificially on the fetal and maternal side. The relative transfer rates of radioactive labelled D-glucose, L-glucose, D-mannose and D-mannitol across the placenta are measured and the inhibition of these transports by phloretin is studied: 1. Transfer rates of D-glucose and D-mannose exceed that of L-glucose about 1.5-4 times. 2. Phloretin (10(-3) mol/l) decreases the transports of D-hexoses, whereas the transport of L-GLUCOSE REMAINS UNAFFECTED. 3. If the concentration of D-glucose is increased, the transport of D-mannose is inhibited competitively. 4. L-glucose and D-mannitol equal in transfer rates. These results show, that D-hexoses cross the human placenta by a specific carrier and by simple diffusion.
对足月人胎盘的分离叶状绒毛膜进行胎儿侧和母体侧的人工灌注。测量放射性标记的D -葡萄糖、L -葡萄糖、D -甘露糖和D -甘露醇跨胎盘的相对转运速率，并研究根皮素对这些转运的抑制作用：1. D -葡萄糖和D -甘露糖的转运速率比L -葡萄糖高约1.5 - 4倍。2. 根皮素（10⁻³mol/l）降低D -己糖的转运，而L -葡萄糖的转运不受影响。3. 如果增加D -葡萄糖的浓度，D -甘露糖的转运受到竞争性抑制。4. L -葡萄糖和D -甘露醇的转运速率相等。这些结果表明，D -己糖通过特定载体和简单扩散穿过人胎盘。
