Alm A, Törnquist P, Mäepea O
Acta Physiol Scand. 1981 Sep;113(1):81-4. doi: 10.1111/j.1748-1716.1981.tb06865.x.
The uptake index method was used for studies on the passage of various monosaccharides across the blood-retinal and the blood-brain barriers in albino rats. The results indicate large similarities for the hexose transport through the two barriers. Thus a stereo-specific, saturable transport of glucose was observed for both barriers. The carriers involved showed measurable affinity for 2-deoxy-D-glucose, 3-0-methyl-D-glucose, D-mannose and D-galactose, but not for L-glucose, D-fructose or D-ribose. The relative affinities of the various hexoses to the carriers were similar. Phloretin and phloridzin both reduced retinal and brain uptake of D-glucose.
摄取指数法被用于研究白化大鼠中各种单糖通过血视网膜屏障和血脑屏障的过程。结果表明己糖通过这两种屏障的转运有很大的相似性。因此，在这两种屏障中均观察到了葡萄糖的立体特异性、可饱和转运。所涉及的载体对2-脱氧-D-葡萄糖、3-O-甲基-D-葡萄糖、D-甘露糖和D-半乳糖表现出可测量的亲和力，但对L-葡萄糖、D-果糖或D-核糖则没有。各种己糖对载体的相对亲和力相似。根皮素和根皮苷均降低了视网膜和脑对D-葡萄糖的摄取。
