Schiffman D O
JAMA. 1977 Oct 3;238(14):1547-50.
Amikacin sulfate, the first semisynthetic aminoglycoside antibiotic introduced in this country, is resistant to the bacterial enzymes that specifically inactivate kanamycin sulfate, gentamicin sulfate, and tobramycin sulfate. This agent is potentially effective, therefore, against many serious infections caused by Gram-negative organisms resistant to other aminoglycosides. It appears to be similar to gentamicin in its in vitro spectrum, in clinical applications, and in the incidence and severity of adverse reactions reported. Like the other drugs in this class, amikacin can cause renal and otic toxic reactions.
硫酸阿米卡星是我国引进的第一种半合成氨基糖苷类抗生素，对能使硫酸卡那霉素、硫酸庆大霉素和硫酸妥布霉素特异性失活的细菌酶具有抗性。因此，该药对由耐其他氨基糖苷类药物的革兰氏阴性菌引起的许多严重感染可能有效。在体外抗菌谱、临床应用以及所报道的不良反应的发生率和严重程度方面，它似乎与庆大霉素相似。与该类中的其他药物一样，阿米卡星可引起肾毒性和耳毒性反应。
