Neidlein R, Stumpf U
Arzneimittelforschung. 1977;27(6):1162-6.
6 metabolites are formed by incubation of grandiflorenic acid (GFA) with rat liver microsomes. 79% of GFA are metabolized after i.p. application to rats; 11 biotransformation products are found in faeces, the main excretion way. They are conjugated to glucuronic acid. Gut microflora is involved in these metabolic reactions. The structure of three metabolites is proved by IR-, MS- and NMR-spectroscopies.
将大花酸（GFA）与大鼠肝微粒体一起孵育可形成6种代谢产物。给大鼠腹腔注射后，79%的GFA会发生代谢；在主要排泄途径粪便中发现了11种生物转化产物。它们与葡萄糖醛酸结合。肠道微生物群参与了这些代谢反应。通过红外光谱、质谱和核磁共振光谱证实了三种代谢产物的结构。
