大花酸[贝壳杉二烯-9(11),16-十八酸]的生物转化和药代动力学。第三次通讯（作者译）
[Biotransformation and pharmacokinetics of grandiflorenic acid [kauradien-9(11),16-oic acid-18]. 3rd communication (author's transl)].
作者信息
Neidlein R, Stumpf U
出版信息
Arzneimittelforschung. 1977 Jul;27(7):1384-90.
PMID:578458
Abstract
Absorption, metabolism and excretion of 14C-GFA following i.v., i.p. and oral application are investigated in rats. After i.p. administration GFA is completely absorbed, after oral dosage about 83% are absorbed. GFA is excreted by 100% via bile and undergoes extensive enterohepatic circulation. After administration of 20 mg/kg 14C-GFA nearly all radioactivity is eliminated after 96 h, more than 80% via the faeces.
摘要
在大鼠中研究了静脉注射、腹腔注射和口服给药后14C-GFA的吸收、代谢和排泄情况。腹腔注射给药后，GFA被完全吸收，口服给药后约83%被吸收。GFA通过胆汁100%排泄，并经历广泛的肠肝循环。给予20mg/kg 14C-GFA后，几乎所有放射性在96小时后被消除，超过80%通过粪便排出。
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