Metz G, Specker M, Sterner W, Heisler E, Grahwit G
Arzneimittelforschung. 1977;27(6):1173-7. doi: 10.1002/chin.197746247.
1-(Theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (ML 1024) was tested on acute and chronic toxicity, on teratogenesis and fetotoxicity, on blood pressure and blood flow behaviour, on hypolipemic activity and general pharmacological behaviour in a screening test using 54 parameters. Results warrant further investigation of the potential therapeutic application of ML 1024 in humans based on its superiority to the well-known antilipemic clofibrate (CPIB).
1-(7-茶碱基)-乙基-2-[2-(对氯苯氧基)-2-甲基丙酸酯](ML 1024)在急性和慢性毒性、致畸性和胚胎毒性、血压和血流行为、降血脂活性以及使用54个参数的筛选试验中的一般药理行为等方面进行了测试。结果表明,基于ML 1024相对于著名的降血脂药物氯贝丁酯(CPIB)的优越性,有必要进一步研究其在人类中的潜在治疗应用。