乙氧茶碱氯贝酸酯（一种乙氧茶碱与氯贝酸的新型酯化物）的降血脂活性评估以及与已知降血脂药物效果的比较。
Evaluation of the hypolipaemic activity of etofylline clofibrate, a new ester of etofylline and clofibric acid, and comparison with effects of known hypolipaemic agents.
作者信息
Davies J E, Kellett D N
出版信息
Arzneimittelforschung. 1980;30(11b):2035-7.
PMID:7194055
Abstract
1-(Theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methylpropionate] (etofylline clofibrate, ML 1024, Duolip) was compared with several reference compounds for effects on serum cholesterol and triglyceride levels of hypercholesterolaemic rats. ML 1024 appeared to be superior to the reference compounds in reducing cholesterol and triglyceride levels and may have a different mechanism of action to clofibrate.
摘要
1-（茶碱-7-基）-乙基-2-[2-（对氯苯氧基）-2-甲基丙酸酯]（益多酯，ML 1024，多利平）与几种参比化合物比较对高胆固醇血症大鼠血清胆固醇和甘油三酯水平的影响。在降低胆固醇和甘油三酯水平方面，ML 1024似乎优于参比化合物，其作用机制可能与氯贝丁酯不同。
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