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Ca2+-transport inhibition by the antitumor agents adriamycin and daunomycin.

作者信息

Anghileri L J

出版信息

Arzneimittelforschung. 1977;27(6):1177-80.

PMID:578437
Abstract

The antitumor agents adriamycin and daunomycin inhibit Ca2+-transport in mitochondria from Ehrlich ascites carcinoma cells as well as in a biphasic model system. The experimental results indicate that both antibiotics interact with phospholipids. The significance of these observations in the pharmacological behavior of these anticancer compounds is discussed.

摘要

相似文献

1
Ca2+-transport inhibition by the antitumor agents adriamycin and daunomycin.
Arzneimittelforschung. 1977;27(6):1177-80.
2
[Membrane-bound Ca2+ in the mitochondria of Ehrlich ascitic tumor cells].[艾氏腹水瘤细胞线粒体中的膜结合钙2+]
Biull Eksp Biol Med. 1985 Nov;100(11):563-6.
3
Inhibition of oxidative phosphorylation in tumor cells and mitochondria by daunomycin and adriamycin.
Biochem Pharmacol. 1976 Sep 15;25(18):2085-9. doi: 10.1016/0006-2952(76)90434-2.
4
[Ca2+ ion transport in the mitochondria of Ehrlich ascites tumor cells].[艾氏腹水癌细胞线粒体中的钙离子运输]
Biull Eksp Biol Med. 1977 Aug;84(8):202-5.
5
Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.阿霉素、柔红霉素、维拉帕米和三氟拉嗪对由12-O-十四烷酰佛波醇-13-乙酸酯引发的与小鼠皮肤肿瘤促进相关生化过程的调节作用。
Cancer Res. 1989 Oct 1;49(19):5364-70.
6
Membrane fluidity in Ehrlich ascites tumor cells treated with adriamycin.
Biotechnol Appl Biochem. 1986 Apr-Jun;8(2-3):217-21.
7
Role of host defense merchanisms in the antitumor activity of adriamycin and daunomycin in mice.宿主防御机制在阿霉素和柔红霉素对小鼠的抗肿瘤活性中的作用。
J Natl Cancer Inst. 1979 Jul;63(1):61-6.
8
[Action of daunomycin on oxygen consumption by various tissues (hepatic and cerebral tissues and cells of the Ehrlich ascites carcinoma)].[柔红霉素对各种组织（肝脏、脑组织及艾氏腹水癌细胞）耗氧量的作用]
Arch Ital Patol Clin Tumori. 1970 Jul-Dec;13(3):151-3.
9
Cytogenetic investigations on a Ehrlich ascites tumor, and four sublines resistant to daunomycin, adriamycin, vincristine and vinblastine.
Hereditas. 1974;77(2):303-10. doi: 10.1111/j.1601-5223.1974.tb00942.x.
10
Doxorubicin (Adriamycin) transport in Ehrlich ascites tumour cells: comparison with transport in human red blood cells.阿霉素（阿德里亚霉素）在艾氏腹水癌细胞中的转运：与在人红细胞中转运的比较。
Scand J Clin Lab Invest. 1983 May;43(3):241-8.

引用本文的文献

1
Cardiotoxic effects of anthracyclines.蒽环类药物的心脏毒性作用。
West J Med. 1983 Sep;139(3):369-71.
2
Cytolytic T lymphocytes and antibodies to myocytes in adriamycin-treated BALB/c mice. Evidence for immunity to drug-induced antigens.阿霉素处理的BALB/c小鼠中的细胞毒性T淋巴细胞和抗心肌细胞抗体。对药物诱导抗原免疫的证据。
Am J Pathol. 1992 Jan;140(1):233-42.
3
Cardiotoxic effects of antitumor agents.抗肿瘤药物的心脏毒性作用。
Cancer Chemother Pharmacol. 1978;1(1):24-34. doi: 10.1007/BF00253143.