Kuzina N V, Aleksandrova G M, Novikova G V, Milogradova G P
Farmakol Toksikol. 1977 May-Jun;40(3):272-7.
In comparing the neurotropic action of probon and amidopyrine it became evident that both analgesics inhibit the behavioral reactions of rats in "open field" tests, fail to produce any protective action with respect to the reflex reaction of the heart in response to pain stimulation and attenuate such an effect of seduxen. By lengthening the hexobarbital-induced sleep probon and amidopyrine change the EEG nature typical of the effect produced by barbiturates. The difference between the study analgesics is rather a quantitative one, viz. in many rests probon is more potent and its action manifestes itself in a wider range of dosages.
在比较丙磺舒和氨基比林的神经亲和作用时发现，这两种镇痛药在“旷场”试验中均能抑制大鼠的行为反应，对心脏对疼痛刺激的反射反应均无任何保护作用，且能减弱速可眠的这种作用。丙磺舒和氨基比林通过延长己巴比妥诱导的睡眠时间，改变了巴比妥类药物产生的典型脑电图特征。所研究的这两种镇痛药之间的差异主要是量的差异，即：在许多情况下，丙磺舒的效力更强，其作用在更广泛的剂量范围内表现出来。
