Ladinskaia M Iu, Kravtsova G N, El'tsova Z I
Farmakol Toksikol. 1975 Sep-Oct;38(5):551-5.
The effect of neurotropics (analgetics and tranquilizers) on the permeability of histo-blood barriers in normalcy and pathology was wound to be dissimilar. In tests conducted on intact rats the studied neurotropic agents used in pharmacological doses did not affect the permeability of the histological-blood barriers of the brain and spleen with respect to the indicator--sodium sulfacyl. In rats with an inflammation focus the same drugs produced changes of the said factor, not always similar in their orientation (rise of fall).
已发现神经营养药物(镇痛药和镇静剂)在正常和病理状态下对组织-血屏障通透性的影响有所不同。在对完整大鼠进行的试验中,以药理剂量使用的所研究神经营养药物,对于指标——磺胺醋酰而言,并未影响脑和脾的组织-血屏障的通透性。在有炎症病灶的大鼠中,相同药物使上述因素发生变化,但其变化方向并不总是相同(升高或降低)。