Vasil'ev Iu N, Ignatov Iu D
Farmakol Toksikol. 1978 Nov-Dec;41(6):676-9.
The analgetic action of probone as compared to that of morphine was studied in chronic tests on cats. Changes in individual signs of a complex reaction in response to a graded stimulation of the cutaneous nerve were assessed. Probone in doses of 50--150 mg/kg and morphine in doses of 2--4 mg/kg raised the threshold of the flexor reflex and reduced manifestations of the emotional-behavioral and vegeto-motor reactions of the animals. But unlike morphine probone did not suppress the vocal reaction, this being a specific component of the response to pain. It is assumed that the change in the response reaction occurring under the effect of probone is due not so much to its analgetic action, but rather to the myorelax and tranquilizing effects.
在对猫进行的慢性试验中，研究了丙泊酚与吗啡相比的镇痛作用。评估了对皮肤神经进行分级刺激时复杂反应的各个体征变化。50 - 150毫克/千克剂量的丙泊酚和2 - 4毫克/千克剂量的吗啡提高了屈肌反射阈值，并减少了动物情绪行为和植物神经运动反应的表现。但与吗啡不同的是，丙泊酚并未抑制发声反应，而发声反应是对疼痛反应的一个特定组成部分。据推测，丙泊酚作用下反应的变化与其说是由于其镇痛作用，不如说是由于其肌松和镇静作用。
