Vilallonga F A, Garrett E R, Hunt J S
J Pharm Sci. 1977 Sep;66(9):1229-34. doi: 10.1002/jps.2600660906.
The free energies of adsorption of the C1 to C14 alkanols at the air--water interface, estimated from plots of the surface pressure (pi less than or equal to 5 dynes/cm) against the bulk concentration, were a linear function of the chain length for 1-alkanols. From C3 to C8, the 2- and 3-isomers showed lower values than the 1-isomers. The energies of interaction of the C1 to C14 alkanols with dipalmitoylphosphatidylethanolamine and dipalmitoyllecithin monolayers, previously spread at the air-water interface, were estimated from the increase of the surface pressure with increasing concentrations of the injected alkanol. The energies of interaction of the C1 to C5 1-alkanols were linear functions of the chain length. The energy of interaction per methylene group of the alkyl chain suggests that the phospholipid monolayers behaved as ultrathin "oil" phases. The 2- and 3-isomers presented marked departures from linearity. The literature data for reflection coefficients in biomembranes and for partition coefficients between olive oil and water, red cell membranes and water, and phospholipid liposomes and water for the C1 to C5 alkanols show similar linearities with the chain length for the 1-isomers and comparable departures for the 2- and 3-isomers.
根据表面压力（π≤5达因/厘米）对本体浓度的曲线估计，C1至C14链烷醇在空气 - 水界面的吸附自由能对于直链烷醇而言是链长的线性函数。从C3到C8，2 - 异构体和3 - 异构体的值低于直链异构体。通过注入链烷醇浓度增加时表面压力的增加来估计C1至C14链烷醇与预先铺展在空气 - 水界面的二棕榈酰磷脂酰乙醇胺和二棕榈酰卵磷脂单层的相互作用能。C1至C5直链烷醇的相互作用能是链长的线性函数。烷基链每个亚甲基的相互作用能表明磷脂单层表现为超薄的“油”相。2 - 异构体和3 - 异构体呈现出明显的非线性。关于C1至C5链烷醇在生物膜中的反射系数以及在橄榄油与水、红细胞膜与水、磷脂脂质体与水之间的分配系数的文献数据显示，直链异构体的链长具有相似的线性关系，而2 - 异构体和3 - 异构体则有类似的偏差。
