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阿霉素与磷脂单层的相互作用。

Interaction of doxorubicin with phospholipid monolayers.

作者信息

Vilallonga F A, Phillips E W

出版信息

J Pharm Sci. 1978 Jun;67(6):773-5. doi: 10.1002/jps.2600670610.

DOI:10.1002/jps.2600670610
PMID:660452
Abstract

The energies of interaction of doxorubicin hydrochloride and sodium 1,2,4-trihydroxy-9,10-dioxo-3-anthracenesulfonate with dipalmitoylphosphatidylethanolamine and dipalmitoyllecithin monolayers spread at the air-water interface were estimated from the increase in surface pressure with increasing concentrations of the subphase-injected compound. Their orders of magnitude were consistent with those of the energies of interaction of doxorubicin and acridines with double-stranded DNA, which suggests that the same type of van der Waals forces are operative.

摘要

通过随着亚相注入化合物浓度增加表面压力的升高,估算了盐酸多柔比星和1,2,4 - 三羟基 - 9,10 - 二氧代 - 3 - 蒽磺酸钠与在空气 - 水界面铺展的二棕榈酰磷脂酰乙醇胺和二棕榈酰卵磷脂单分子层的相互作用能。它们的量级与多柔比星和吖啶与双链DNA的相互作用能的量级一致,这表明存在相同类型的范德华力作用。

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