Barkhina T G, Tomilets V A
Arkh Patol. 1977;39(6):25-9.
The electron microscopic examination of livers of guinea pigs treated with heterologous mitochondrial antibody showed that under these circumstances pathological changes developed in hepatocytes entailing various disorders of cell metabolism. These changes consisted in marked disturbance of the circulation of intracellular fluids leading to the general or partial edema of the cell and disorientation of organoids, in different rearrangements of mitochondria with loss of calcium phosphate salts, in degranulation and formation of numerous large cavities of granular endoplasmic reticulum, reduction of the Golgi complex, decrease in the amount or complete lack of glycogen in hepatocytes. The experimental evidence attests to the damaging effect of heterologous mitochondrial antibody on numerous cellular and subcellular structures causing the disorders in the water-salt, protein, and carbohydrate metabolism.
用异种线粒体抗体处理的豚鼠肝脏的电子显微镜检查表明，在这些情况下，肝细胞会发生病理变化，导致细胞代谢出现各种紊乱。这些变化包括细胞内液循环明显紊乱，导致细胞普遍或局部水肿以及细胞器排列紊乱；线粒体发生不同的重排，伴有磷酸钙盐丢失；颗粒内质网脱颗粒并形成许多大腔；高尔基体复合体减少；肝细胞中糖原数量减少或完全缺乏。实验证据证明异种线粒体抗体对许多细胞和亚细胞结构具有破坏作用，从而导致水盐、蛋白质和碳水化合物代谢紊乱。
