[Submicroscopic changes in the hepatocytes of guinea pigs under the effect of heterologous mitochondrial antibodies].

The electron microscopic examination of livers of guinea pigs treated with heterologous mitochondrial antibody showed that under these circumstances pathological changes developed in hepatocytes entailing various disorders of cell metabolism. These changes consisted in marked disturbance of the circulation of intracellular fluids leading to the general or partial edema of the cell and disorientation of organoids, in different rearrangements of mitochondria with loss of calcium phosphate salts, in degranulation and formation of numerous large cavities of granular endoplasmic reticulum, reduction of the Golgi complex, decrease in the amount or complete lack of glycogen in hepatocytes. The experimental evidence attests to the damaging effect of heterologous mitochondrial antibody on numerous cellular and subcellular structures causing the disorders in the water-salt, protein, and carbohydrate metabolism.