利血平对小鼠心脏中3H-α-甲基去甲肾上腺素亚细胞分布的影响。
Effect of reserpine on the subcellular distribution of 3H-alpha-methylnoradrenaline in the mouse heart.
作者信息
Lundborg P
出版信息
Br J Pharmacol. 1969 Jun;36(2):386-92. doi: 10.1111/j.1476-5381.1969.tb09514.x.
Abstract
- Mice were injected with reserpine (0.5 mg/kg or 2.5 mg/kg) at various intervals after an intravenous injection of (3)H-alpha-methylnoradrenaline ((3)H-alpha-MeNa), 20 mug or 100 mug/kg. The effect of reserpine on the content of labelled amine in the subcellular fractions of the heart was studied.2. In most experiments reserpine caused a pronounced decrease in the (3)H-alpha-MeNA content of the particulate fraction (P). The decrease was most pronounced when the higher dose of reserpine and lower dose of alpha-MeNA were used. In most experiments, the (3)H-alpha-MeNA content of the supernatant fractions was unchanged and, therefore, the P/(P + S) ratio was decreased.3. It is concluded that the effect of reserpine is a releasing effect on the particulate (granular) fraction, probably by blocking the re-uptake of the amine leaked from the granules. No support was found for the hypothesis that reserpine acts by inhibition of release of amines from the nerve granules.
摘要
在静脉注射20微克或100微克/千克的（3）H-α-甲基去甲肾上腺素（（3）H-α-MeNa）后的不同时间间隔，给小鼠注射利血平（0.5毫克/千克或2.5毫克/千克）。研究了利血平对心脏亚细胞组分中标记胺含量的影响。
在大多数实验中，利血平导致颗粒组分（P）的（3）H-α-MeNA含量显著降低。当使用较高剂量的利血平和较低剂量的α-MeNA时，这种降低最为明显。在大多数实验中，上清液组分的（3）H-α-MeNA含量未发生变化，因此，P/（P + S）比值降低。
得出的结论是，利血平的作用是对颗粒（颗粒状）组分产生释放作用，可能是通过阻断从颗粒中泄漏的胺的再摄取。未发现支持利血平通过抑制神经颗粒中胺的释放起作用这一假说的证据。
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