Panovskaia G N, Iashchenko L V, Nesterov E N, Kobozov G V
Biull Eksp Biol Med. 1977 Sep;84(9):286-8.
The state of pulmonary surfactant in rabbits at different periods (3 to 60 days) of experimental pneumonia was compared with the changes of the redox enzymes in the alveolar epithelium and the cells of the inflammatory infiltrate. At the initial stage (3 to 7 days) of the cellular metabolism activation there occurred a transitory intensification of the synthesis of surfactant lipids with a relative suppression of phospholipid synthesis. Later the progress of dystrophic processes and parenchymal sclerosis was accompanied by reduction of the synthesis of all the surfactant components. Surfactant surface activity became stable at a low level. This is possibly connected with the specific regulation of the surfactant synthesis determined by functional peculiarities of the organ.
将实验性肺炎不同时期（3至60天）家兔肺表面活性物质的状态与肺泡上皮及炎性浸润细胞中氧化还原酶的变化进行了比较。在细胞代谢激活的初始阶段（3至7天），表面活性物质脂质合成出现短暂增强，而磷脂合成相对受抑制。随后，营养不良过程和实质硬化的进展伴随着所有表面活性物质成分合成的减少。表面活性物质的表面活性在低水平保持稳定。这可能与该器官功能特性所决定的表面活性物质合成的特定调节有关。
