NZBxNZW F1 杂交小鼠的免疫反应。
The immune response in NZBxNZW F1 hybrid mice.
作者信息
Salomon J C, Benveniste J
出版信息
Clin Exp Immunol. 1969 Feb;4(2):213-25.
Abstract
A study was made of the immune response of NZB × NZW F hybrid (BW) mice against `H' antigen of , sheep red blood cells, bovine serum albumin and allogeneic tumour cells. The responses of old BW mice having autoimmune glomerulonephritis were compared with those of young healthy mice. It was found that the mice develop immune depression concurrently with the autoimmune process. In old BW mice, the immune response is of the same type as the response observed in neonatally thymectomized mice. Neither age alone, nor functional deficiency of the thymus could account for this immune depression. It is suggested that the ability to respond to foreign antigens was probably depressed by the competition provided by autoantigens.
摘要
对NZB×NZW F1杂种（BW）小鼠针对绵羊红细胞的“H”抗原、牛血清白蛋白和同种异体肿瘤细胞的免疫反应进行了研究。将患有自身免疫性肾小球肾炎的老年BW小鼠的反应与年轻健康小鼠的反应进行了比较。发现这些小鼠在自身免疫过程中同时出现免疫抑制。在老年BW小鼠中，免疫反应与新生期胸腺切除小鼠中观察到的反应类型相同。单独的年龄或胸腺功能缺陷都不能解释这种免疫抑制。有人提出，对外来抗原的反应能力可能因自身抗原提供的竞争而受到抑制。
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本文引用的文献
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