衰老CBA和NZB小鼠淋巴样细胞群的变化。
Changes in lymphoid populations of ageing CBA and NZB mice.
作者信息
Zatz M M, Mellors R C, Lance E M
出版信息
Clin Exp Immunol. 1971 Mar;8(3):491-500.
Abstract
Changes in subpopulations of lymphoid cells of normal (CBA) and autoimmune (NZB) mice were studied as a function of age, by observing migration patterns of Cr labelled lymph node, spleen and thymus cells from donors aged 8 days to 12 months. The method permits analysis of the proportions and numbers of recirculating and non-recirculating lymphocytes in lymphoid compartments. Changes in the lymphoid populations of CBA mice were found, which could be attributed to the normal processes of maturation and senescence. In NZB mice relative and absolute decreases in the recirculating cell content of lymph node and spleen were observed which coincided with the time of development of autoimmunity. The significance of these results, in relation to altered immunocompetence with age, is discussed.
摘要
通过观察8天至12个月龄供体的铬标记淋巴结、脾脏和胸腺细胞的迁移模式，研究了正常（CBA）和自身免疫（NZB）小鼠淋巴样细胞亚群随年龄的变化。该方法可分析淋巴样区室中再循环和非再循环淋巴细胞的比例和数量。发现CBA小鼠的淋巴样群体发生了变化，这可归因于成熟和衰老的正常过程。在NZB小鼠中，观察到淋巴结和脾脏再循环细胞含量的相对和绝对下降，这与自身免疫的发展时间一致。讨论了这些结果与年龄相关的免疫能力改变的关系。
相似文献
1
Changes in lymphoid populations of ageing CBA and NZB mice.衰老CBA和NZB小鼠淋巴样细胞群的变化。
Clin Exp Immunol. 1971 Mar;8(3):491-500.
2
[Histological study on lung, spleen, lymph nodes and thymus gland in New Zealand mice in a longitudinal time study].[新西兰小鼠肺、脾、淋巴结和胸腺的纵向时间组织学研究]
Allerg Immunol (Leipz). 1973;19(1):9-27.
3
4
Effects of cortisol and antilymphocyte serum on lymphoid populations.
Ciba Found Study Group. 1970;36:73-99.
5
Erythrokinetic effect of parental spleen cells in hybrid mice.亲代脾细胞对杂种小鼠的红细胞动力学效应
Arch Pathol. 1965 Oct;80(4):397-408.
6
7
Autoimmune reactions and malignant changes in germ-free New Zealand Black mice.无菌新西兰黑鼠的自身免疫反应和恶性变化
Clin Exp Immunol. 1969 Jun;4(6):621-35.
8
The dynamics of graft-versus-host reaction across a strong and weak histocompatibility barrier.跨越强弱组织相容性屏障的移植物抗宿主反应动力学
Folia Biol (Praha). 1968;14(5):372-82.
9
[Influence of the thymus gland on lymphoid regeneration in the rat after administration of lethal doses of myleran and a marrow graft].[给予致死剂量马利兰及骨髓移植后胸腺对大鼠淋巴组织再生的影响]
Pathol Biol (Paris). 1969 Apr;17(7):365-9.
10
Effects of lymphoid depletion on the distribution of 51Cr-labeled lymph node cells in mice.淋巴细胞清除对51Cr标记的小鼠淋巴结细胞分布的影响。
Transplantation. 1971 Jun;11(6):536-42.
引用本文的文献
1
The effect of aging and caloric restriction on murine CD8+ T cell chemokine receptor gene expression.衰老和热量限制对小鼠 CD8+T 细胞趋化因子受体基因表达的影响。
Immun Ageing. 2007 Nov 14;4:8. doi: 10.1186/1742-4933-4-8.
2
Lyt phenotype, lymphocyte migration and the selective tissue positioning of mouse T cell sets.Lyt表型、淋巴细胞迁移与小鼠T细胞亚群的选择性组织定位
Immunology. 1984 Jun;52(2):331-9.
3
The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping.51铬标记淋巴细胞在抗原刺激小鼠体内的分布。淋巴细胞滞留。
J Exp Med. 1971 Jul 1;134(1):224-41. doi: 10.1084/jem.134.1.224.
4
Peripheral blood lymphocyte cell surface markers during the course of systemic lupus erythematosus.系统性红斑狼疮病程中的外周血淋巴细胞表面标志物
J Clin Invest. 1973 Dec;52(12):3046-56. doi: 10.1172/JCI107503.
5
Thymosin corrects the abnormal DNA synthetic response of NZB mouse thymocytes.胸腺素可纠正新西兰黑小鼠胸腺细胞异常的DNA合成反应。
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2637-41. doi: 10.1073/pnas.71.7.2637.
6
Alteration in DNA synthetic response of thymocytes from NZB mice of different ages.不同年龄NZB小鼠胸腺细胞DNA合成反应的改变。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3769-72. doi: 10.1073/pnas.70.12.3769.
7
Studies on thymus products. IV. Absence of serum 'thymic activity' in adult NZB and (NZB x NZW) F1 mice.胸腺产物的研究。IV. 成年NZB和（NZB×NZW）F1小鼠血清中不存在“胸腺活性”
Clin Exp Immunol. 1973 Jun;14(2):247-56.
8
Age-decrease of cells sensitive to an autoantibody-specific for thymocytes and thymus-dependent lymphocytes in NZB mice.NZB小鼠中对胸腺细胞和胸腺依赖性淋巴细胞特异性自身抗体敏感的细胞数量随年龄减少。
Clin Exp Immunol. 1972 Dec;12(4):455-64.
9
Natural cytotoxic autoantibody against thymocytes in NZB mice.针对NZB小鼠胸腺细胞的天然细胞毒性自身抗体。
Clin Exp Immunol. 1972 Sep;12(1):133-52.
10
T and B lymphocytes in New Zealand black mice. An analysis of the theta, TL and MBLA markers.新西兰黑鼠中的T淋巴细胞和B淋巴细胞。对θ、TL和MBLA标记物的分析。
Clin Exp Immunol. 1972 May;11(1):1-11.
本文引用的文献
1
AUTOIMMUNE DISEASE IN NZB/BL MICE. I. PATHOLOGY AND PATHOGENESIS OF A MODEL SYSTEM OF SPONTANEOUS GLOMERULONEPHRITIS.NZB/BL小鼠的自身免疫性疾病。I. 自发性肾小球肾炎模型系统的病理学与发病机制
J Exp Med. 1965 Jul 1;122(1):25-40. doi: 10.1084/jem.122.1.25.
2
Review lectures on senescence. II. Heterochronic transplantation in the study of ageing.衰老综述讲座。II. 衰老研究中的异时移植
Proc R Soc Lond B Biol Sci. 1962 Dec 18;157:128-47. doi: 10.1098/rspb.1962.0066.
3
Growth and senescence of antibody-forming cells.抗体形成细胞的生长与衰老
J Cell Physiol. 1966 Jun;67(3):Suppl 1:185+. doi: 10.1002/jcp.1040670415.
4
A deficient development of the thymic epithelium and auto-immune disease in NZB mice.NZB小鼠胸腺上皮发育缺陷与自身免疫性疾病
J Pathol Bacteriol. 1966 Apr;91(2):487-94. doi: 10.1002/path.1700910223.
5
The immune response in NZBxNZW F1 hybrid mice.NZBxNZW F1 杂交小鼠的免疫反应。
Clin Exp Immunol. 1969 Feb;4(2):213-25.
6
Response of NZB mice to foreign antigen and development of autoimmune disease.新西兰黑鼠对外源抗原的反应及自身免疫性疾病的发展。
J Reticuloendothel Soc. 1969 Feb;6(1):78-93.
7
Segregation of lymphocyte populations through differential migration.通过差异迁移实现淋巴细胞群体的分离。
Nature. 1969 Mar 1;221(5183):841-3. doi: 10.1038/221841a0.
8
An extension of the 51Cr-release assay for the estimation of mouse cytotoxins.用于估计小鼠细胞毒素的51铬释放试验的扩展。
Transplantation. 1968 Sep;6(6):761-4. doi: 10.1097/00007890-196809000-00002.
9
Immune response to a soluble protein antigen in NZB mice.NZB小鼠对可溶性蛋白质抗原的免疫反应。
Nature. 1968 Sep 21;219(5160):1276-7. doi: 10.1038/2191276a0.
10
Strain differences in the immune response of mice. I. The neonatal response to sheep red cells.小鼠免疫反应中的品系差异。I. 对绵羊红细胞的新生反应。
Immunology. 1968 Jul;15(1):35-50.
Zotero 插件