Stern K
Clin Exp Immunol. 1969 Feb;4(2):253-63.
After immunization of rats with heterophilic antigen (boiled homogenates of guinea-pig kidney), their immune responses to sheep red cells were consistently depressed, whereas those to heterophilic antigen were increased, as compared with controls. The suppression of immune responses to sheep red cells in rats immunized with heterophilic antigen may represent an animal model paralleling the interference with Rh immunization of ABO incompatibility in man. Experiments intended to elucidate the mechanism of this interference included simultaneous administration of sheep red cells and heterophilic antigen; comparison of antibody formation in intact and splenectomized rats; and passive immunization with isophilic and/or heterophilic antibodies prior to challenge with sheep red cells. On the basis of the experimental observations, a hypothesis was proposed according to which cellular diversion of antigen may be responsible for these inhibitions of immune responses.
用嗜异性抗原（豚鼠肾煮沸匀浆）免疫大鼠后，与对照组相比，它们对绵羊红细胞的免疫反应持续受到抑制，而对嗜异性抗原的免疫反应则增强。用嗜异性抗原免疫的大鼠对绵羊红细胞免疫反应的抑制可能代表了一种与人类ABO血型不相容对Rh免疫干扰相似的动物模型。旨在阐明这种干扰机制的实验包括同时给予绵羊红细胞和嗜异性抗原；比较完整大鼠和脾切除大鼠的抗体形成；以及在用绵羊红细胞攻击之前用嗜同性和/或嗜异性抗体进行被动免疫。根据实验观察结果，提出了一个假说，即抗原的细胞转移可能是这些免疫反应抑制的原因。
