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[通过向大鼠脑池注射高岭土溶液产生的实验性脑积水(作者译)]

[Experimental hydrocephalus of the rat, produced by cisternal injection of kaolin-solution (author's transl)].

作者信息

Yamaki T, Odake G, Naruse S, Ibata Y, Nojo Y

出版信息

No Shinkei Geka. 1977 Jun;5(6):537-40.

PMID:578917
Abstract

Experimental hydrocephalus was produced in rats in high percentage, by direct injection of kaolin-solution into the cisterna magna under a operating microscope. Rats with hydrocephalus showed retarded development of the body. The skull enlarged round and became so thin, that the cortical vessels were observed through the skull. The brain showed marked internal hydrocephalus, retaining cerebrospinal fluid passage in the ventricular system, but there was an obstruction at the ambient cistern and the basal cistern. Review of the literature dealing with the methods to produce acquired hydrocephalus showed that this is the first report of experimental hydrocephalus of the rat produced by injecting kaolin-solution.

摘要

通过在手术显微镜下将高岭土溶液直接注入大鼠小脑延髓池,以高比例诱导大鼠发生实验性脑积水。脑积水大鼠表现出身体发育迟缓。颅骨呈圆形增大且变薄,以至于透过颅骨可观察到皮质血管。大脑显示出明显的内部脑积水,脑室系统中脑脊液通道保留,但环池和基底池存在梗阻。回顾有关获得性脑积水产生方法的文献表明,这是关于通过注射高岭土溶液诱导大鼠实验性脑积水的首次报道。

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