在存在锂离子和镁离子的情况下，石房蛤毒素和河豚毒素对神经传导的影响。
The effects of saxitoxin and tetrodotoxin on nerve conduction in the presence of lithium ions and of magnesium ions.
作者信息
Evans M H
出版信息
Br J Pharmacol. 1969 Jul;36(3):418-25. doi: 10.1111/j.1476-5381.1969.tb07998.x.
Abstract
- It has been shown that nerve fibres from rat cauda equina will conduct action potentials after immersion in saline in which lithium chloride is substituted for sodium chloride.2. Both saxitoxin and tetrodotoxin inhibit lithium-generated action potentials. The concentration of toxin needed to inhibit the lithium-generated action potentials is similar to that needed to inhibit sodium-generated action potentials.3. If magnesium chloride is added to the saline to give a concentration of 10-15 mM there is usually a slight fall in amplitude of the compound action potential. Saxitoxin and tetrodotoxin now inhibit the action potential to a greater degree than in the absence of magnesium ions.
摘要
已表明，大鼠马尾神经纤维浸入用氯化锂替代氯化钠的盐溶液后能传导动作电位。
石房蛤毒素和河豚毒素均抑制锂引发的动作电位。抑制锂引发动作电位所需的毒素浓度与抑制钠引发动作电位所需的浓度相似。
如果向盐溶液中加入氯化镁使其浓度达到10 - 15 mM，复合动作电位的幅度通常会略有下降。与不存在镁离子时相比，石房蛤毒素和河豚毒素现在对动作电位的抑制作用更大。
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本文引用的文献
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J Gen Physiol. 1951 Nov;35(2):227-44. doi: 10.1085/jgp.35.2.227.
2
Effects of tetrodotoxin on the neuromuscular junction.河豚毒素对神经肌肉接头的作用。
Jpn J Physiol. 1959 Jun 25;9(2):143-52. doi: 10.2170/jjphysiol.9.143.
3
The hyperpolarization which follows activity in mammalian non-medullated fibres.哺乳动物无髓鞘纤维活动后出现的超极化。
J Physiol. 1957 Apr 3;136(1):80-97. doi: 10.1113/jphysiol.1957.sp005744.
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