Hafner D, Heinen E, Noack E
Arzneimittelforschung. 1977;27(10):1871-3.
The mathematical analysis of concentration-response relationships is performed by means of the mass law and the drug-receptor theory. It is demonstrated that the calculation of the median effective dose (ED50), which is decisive for the pharmacological characterisation of a certain drug, may only be effected by means of the logit transformation. In addition, it is shown that this transformation is most suitable to evaluate in a mathematically simple way the number of drug binding sites of the receptor molecule.
浓度-反应关系的数学分析是通过质量作用定律和药物-受体理论来进行的。结果表明，对于某种药物的药理学特性起决定性作用的半数有效剂量（ED50）的计算，只能通过对数转换来实现。此外，还表明这种转换最适合以数学上简单的方式评估受体分子的药物结合位点数量。
