与阿马林相比，N-丙基阿马林的荧光数据以及脂溶性和化学结构研究。
Fluorescence data and studies on the lipid solubility and chemical structure of N-propyl-ajmaline as compared to ajmaline.
作者信息
Iven H
出版信息
Arzneimittelforschung. 1977;27(10):1875-9.
PMID:579095
Abstract
The quaternary N-propyl-ajmaline was found to have a higher lipid solubility than ajmaline. Lipid solubility was pH dependent. From chemical, fluorescence and IR-spectroscopic studies it is concluded that the existence of N-propyl-ajmaline in a tautomeric state between a carbinol-ammonium and an aldehyde-amine structure is responsible for the high lipid solubility.
摘要
已发现季铵型N-丙基阿马林的脂溶性高于阿马林。脂溶性取决于pH值。通过化学、荧光和红外光谱研究得出结论，N-丙基阿马林在甲醇铵和醛胺结构之间以互变异构状态存在是其高脂溶性的原因。
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