Tsunenari Y, Kast A
Arzneimittelforschung. 1977;27(10):1979-82.
In case of intravenous injection into caudal veins of rats, the occasional inoculation of hair particles into the lumen of the vein cannot be avoided. These hairs either cause a local thrombophlebitis or are floated with the blood stream until they are thoughout caught by the pulmonary filters, even if they measure less than 10 mu in length. In capillaries or alveoli of lungs phagocytosis by giant cells will start after about 3 days and will be fully terminated within four weeks.
如果向大鼠尾静脉进行静脉注射,难免会偶尔将毛发颗粒接种到静脉腔内。这些毛发要么引起局部血栓性静脉炎,要么随血流漂浮,直到它们被肺滤器完全捕获,即使它们的长度小于10微米。在肺部的毛细血管或肺泡中,大约3天后巨噬细胞会开始吞噬作用,并在四周内完全结束。