Kast A
Nippon Boehringer Ingelheim Co., Ltd.
Berl Munch Tierarztl Wochenschr. 1995 Feb;108(2):61-5.
Among 1422 Sprague-Dawley rats treated daily for 28 consecutive days by i.v. injections, 779 animals (55.8%) showed lesions at the site of injection. 381 rats (26.8%) had pulmonary emboli with fragments of hair or skin in arterial thrombi or in giant cell granulomas. 6 weeks after cessation of treatment lesions were still found in lungs from 5 of 90 rats (5.6%) allowed to recover. In 8 of 64 Himalayan rabbits (12.5%) given 28 injections into ear veins pulmonary embolism was observed. Among 184 rhesus and cynomolgus monkeys treated daily for 28 consecutive days by injection into cephalic or saphenous veins, 167 monkeys (91%) showed lesions at the site of injection, 14 animals (7.6%) had pulmonary emboli with fragments of hair and skin in arterial thrombi or giant cell granulomas.
在1422只通过静脉注射连续28天每日给药的斯普拉格-道利大鼠中，779只动物（55.8%）在注射部位出现病变。381只大鼠（26.8%）发生肺栓塞，在动脉血栓或巨细胞肉芽肿中有毛发或皮肤碎片。停止治疗6周后，在90只恢复的大鼠中有5只（5.6%）的肺部仍发现病变。在64只喜马拉雅兔中，有8只（12.5%）经耳静脉注射28次后观察到肺栓塞。在184只恒河猴和食蟹猴中，通过头静脉或隐静脉连续28天每日给药，167只猴子（91%）在注射部位出现病变，14只动物（7.6%）发生肺栓塞，在动脉血栓或巨细胞肉芽肿中有毛发和皮肤碎片。
