醋酸卤泼尼龙的物理化学与分析研究
Physico-chemical and analytical studies on Halopredone acetate.
作者信息
Toscano L, Guadagnini G, Grisanti G
出版信息
Arzneimittelforschung. 1977;27(9):1636-41.
Physico-chemical, spectroscopic (UV, CD, ORD, IR-1H-DMR, 19F-NMR, PFT13C-NMR, MS), and chromatographic (TLC, HPLC) properties of 17,21-bis(acetyloxy)-2-bromo-6beta,9-difluoro-11beta-hydroxypregna-1,4-diene-3,20-dione (halopredone acetate; Topicon) are reported. Densitometric and high-pressure liquid chromatographic quantitative analytical methods are described. The usual descriptive data, purity tests, potential impurities arising from the synthesis and stability tests are given.
报道了17,21-双（乙酰氧基）-2-溴-6β,9-二氟-11β-羟基孕甾-1,4-二烯-3,20-二酮（醋酸卤泼尼龙；拓米松）的物理化学、光谱（紫外、圆二色、旋光色散、红外-1H-双共振、19F-核磁共振、13C-核磁共振、质谱）和色谱（薄层色谱、高效液相色谱）性质。描述了密度测定法和高压液相色谱定量分析方法。给出了常规描述性数据、纯度测试、合成过程中产生的潜在杂质以及稳定性测试结果。
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