DeSante K A, Stoll R G, Kaiser D G, DiSanto A R
J Pharm Sci. 1977 Dec;66(12):1713-6. doi: 10.1002/jps.2600661214.
Plasma level data on two investigational capsule formulations of propoxyphene with similar physicochemical parameters demonstrate that the formulations have different in vivo bioavailabilities. The potential bioavailability problems with water-soluble drugs and the lack of correlation of in vitro and in vivo parameters for equivalent drug formulations are discussed.
两种具有相似理化参数的丙氧芬试验性胶囊制剂的血浆水平数据表明，这些制剂具有不同的体内生物利用度。文中讨论了水溶性药物潜在的生物利用度问题以及等效药物制剂体外和体内参数缺乏相关性的问题。
