复方片剂（多来痛）中右丙氧芬、乙酰水杨酸和非那宗的生物利用度：个体间差异及食物摄入的影响。

Bioavailability of D-propoxyphene, acetyl salicylic acid, and phenazone in a combination tablet (Doleron): interindividual variation and influence of food intake.

作者信息

Melander A, Berlin-Wahlén A, Bodin N O, Danielson K, Gustafsson B, Lindgren S, Westerlund D

出版信息

Acta Med Scand. 1977;202(1-2):119-24. doi: 10.1111/j.0954-6820.1977.tb16796.x.

DOI:10.1111/j.0954-6820.1977.tb16796.x

Abstract

The influence of food intake on the bioavailability of three analgesic compounds--propoxyphene chloride, acetyl salicylic acid and phenazone--in a combination tablet, Doleron, has been examined in eight healthy volunteers. A single oral dose was given both on an empty stomach and together with a standardized breakfast meal. The plasma concentrations of propoxyphene, its major metabolite norpropoxyphene, salicylic acid and phenazone were determined by mass fragmentography, spectrofluorimetry and gas chromatography. Concomitant food intake had no consistent influence on the bioavailability of any of the components. Hence, doleron may be taken together with meals as well as between meals. Large interindividual variations in propoxyphene and phenazone concentrations were found, indicating that an optimal effect will not always be obtained by standard doses.

摘要

在八名健康志愿者中研究了食物摄入对复方片剂多来龙（Doleron）中三种止痛化合物——氯丙氧芬、乙酰水杨酸和非那宗——生物利用度的影响。在空腹和与标准早餐一起的情况下均给予单次口服剂量。通过质谱碎片分析法、荧光分光光度法和气相色谱法测定丙氧芬、其主要代谢产物去甲丙氧芬、水杨酸和非那宗的血浆浓度。同时摄入食物对任何成分的生物利用度均无一致影响。因此，多来龙既可以与餐同服，也可以在两餐之间服用。发现丙氧芬和非那宗浓度存在较大个体差异，表明标准剂量并不总能获得最佳效果。