二、不同品系大鼠间歇性暴露于寒冷环境后肾上腺髓质核DNA含量的差异
II. Differences in adrenal medulla nuclear DNA content among rats of different strains following intermittent exposure to cold.
作者信息
Tongiani R, Viola-Magni M P
出版信息
J Cell Biol. 1969 Aug;42(2):452-9. doi: 10.1083/jcb.42.2.452.
The amount of DNA per nucleus in the adrenal medulla cells of four different strains of rats (Wistar, Sprague-Dawley, Long-Evans, and Italico) is determined both under control conditions and after 300 hr of intermittent exposure to cold. The adrenal medulla nuclei of the four strains of rats contain the same amount of DNA; however, the loss of DNA observed after the same experimental treatment differs markedly in the different strains. The loss is small in Wistar and Sprague-Dawley rats (8-13%), larger in Long-Evans rats (20%) and still larger in Italico rats (45%). The DNA loss in Wistar rats increases if the animals are fed the same diet as the Italico rats, and the DNA loss in Italico rats is reduced if the animals are fed the same diet as the Wistar rats. The different behavior of the four strains is discussed in terms of turnover of DNA.
在对照条件下以及在间歇性暴露于寒冷300小时后，测定了四种不同品系大鼠（Wistar、Sprague-Dawley、Long-Evans和Italico）肾上腺髓质细胞中每个细胞核的DNA含量。这四种品系大鼠的肾上腺髓质细胞核所含DNA量相同；然而，在相同实验处理后观察到的DNA损失在不同品系中差异显著。Wistar和Sprague-Dawley大鼠的损失较小（8%-13%），Long-Evans大鼠的损失较大（20%），而Italico大鼠的损失更大（45%）。如果给Wistar大鼠喂食与Italico大鼠相同的饮食，其DNA损失会增加；如果给Italico大鼠喂食与Wistar大鼠相同的饮食，其DNA损失会减少。从DNA周转的角度讨论了这四个品系的不同行为。
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