Dupont P A, Sirs J A
Thromb Haemost. 1977 Oct 31;38(3):660-7.
Measurements have been made of plasma fibrinogen concentration, erythrocyte flexibility and blood viscosity at shear rates from 5.75 to 230 sec-1 during and following surgery. In the post-operative period the plasma fibrinogen level in the patient rose to over 1,000 mg/dl and because there were subsequent complications, only returned to normal after 4 weeks. There was an associated change of erythrocyte flexibility, with a correlation coefficient of 0.98. The blood viscosity also varied with the plasma fibrinogen level, the effect being more pronounced at low shear rates. The internal viscosity of the red blood cell, calculated from the plasma viscosity and whole blood viscosity at 230 sec-1, decreases with increasing plasma fibrinogen concentration, in agreement with the direct measurements made of erythrocyte flexibility. It is proposed that at high shear rates an increase in plasma viscosity due to an elevation of fibrinogen concentration, is offset by a decrease in the rigidity of the erythrocytes, and these 2 effects counter-balance.
在手术期间及术后，测量了剪切速率在5.75至230秒⁻¹范围内的血浆纤维蛋白原浓度、红细胞柔韧性和血液粘度。术后患者血浆纤维蛋白原水平升至1000mg/dl以上，由于随后出现并发症，4周后才恢复正常。红细胞柔韧性也有相应变化，相关系数为0.98。血液粘度也随血浆纤维蛋白原水平而变化，在低剪切速率下这种影响更为明显。根据230秒⁻¹时的血浆粘度和全血粘度计算得出的红细胞内粘度，随着血浆纤维蛋白原浓度的增加而降低，这与对红细胞柔韧性的直接测量结果一致。有人提出，在高剪切速率下，纤维蛋白原浓度升高导致的血浆粘度增加，会被红细胞刚性的降低所抵消，这两种效应相互平衡。
